反应详情

温度

200 °C

To a solution of 2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide (50 mg) in acetonitrile (0.5 ml) was added 3-aminobenzonitrile (92 mg, ex Aldrich) and the solution heated at 200° C. under microwave conditions for 45 minutes. Acetonitrile was removed under reduced pressure and ethyl acetate (5 ml) added. The solution was washed sequentially with 2N hydrochloric acid (2×3 ml) and water (3×3 ml), dried (MgSO4), evaporated and the residue purified using silica gel chromatography with 1:1 ethyl acetate:isohexane to afford the title compound (37 mg).

1. customAcetonitrile was removed under reduced pressure and ethyl acetate (5 ml)
2. additionadded
3. washThe solution was washed sequentially with 2N hydrochloric acid (2×3 ml) and water (3×3 ml)
4. dry with materialdried (MgSO4)
5. customevaporated
6. customthe residue purified