HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Chlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid → 2-(3-Chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl-(tetrahydro-pyran-4-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Chlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid | HCID 16719655 | — |
| Reactant | Methyl((oxan-4-yl)methyl)amine hydrochloride | HCID 22737007 | — |
| Product | 2-(3-Chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl-(tetrahydro-pyran-4-ylmethyl)-amide | HCID 57982705 | — |
Reaction Steps
In a manner similar to Reference Example 1 (c) 2-(3-chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (50 mg) and N-methyl-N-(tetrahydro-pyran-4-yl methyl)amine hydrochloride (39 mg) afforded, after Biotage chromatography over silica gel, eluting with 1% MeOH/CH2Cl2, the title compound (33 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07635701B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-e3c413bd38ae4dcab1e52508ba036e4f |
| Source note | uspto-grants-2009_12 |