Cyclopropanemethanamine → HCID 57982633, compound

HRID 1868389Notes

Reaction equation

HRID 1868389 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[C:12]([C:19]([OH:21])=O)=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH:22]1([CH2:25][NH2:26])[CH2:24][CH2:23]1>>[CH:22]1([CH2:25][NH:26][C:19]([C:12]2[C:13]([C:15]([F:18])([F:16])[F:17])=[N:14][C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)=[N:10][CH:11]=2)=[O:21])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 16719434HCID 16719434, compound

Product 1

HCID 57982633HCID 57982633, compoundYield 26.2%

Procedure

In a manner similar to Reference Example 1 (c) 2-(3-bromophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (80 mg) and cyclopropylmethylamine (19 mg, ex Lancaster) afforded the title compound (24 mg). Sample purified by mass directed auto-prep.

Sources & evidence

ORD record
ord-3e1f741dabf94df88f60f71df0113156
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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