Cyclopropanemethanamine → HCID 57982658, compound

HRID 1868390Notes

Reaction equation

HRID 1868390 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[C:13]([C:20]([OH:22])=O)=[CH:12][N:11]=1.[CH:23]1([CH2:26][NH2:27])[CH2:25][CH2:24]1>>[CH:23]1([CH2:26][NH:27][C:20]([C:13]2[C:14]([C:16]([F:19])([F:18])[F:17])=[N:15][C:10]([NH:9][C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[N:11][CH:12]=2)=[O:22])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 16719743HCID 16719743, compound

Product 1

HCID 57982658HCID 57982658, compoundYield 63%

Procedure

In a manner similar to Reference Example 1 (c) 2-(2,4-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (80 mg) and cyclopropylmethylamine (19 mg, ex Lancaster) afforded the title compound (58 mg).

Sources & evidence

ORD record
ord-2eccd4570dfd4e79a176028d573e8ac1
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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