HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-2-fluorobenzotrifluoride → 2-(2-Fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-2-fluorobenzotrifluoride | HCID 145569 | — |
| Reactant | 2-Chloro-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide | HCID 57982581 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(2-Fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide | HCID 57982666 | 15.2% |
Reaction Steps
In a manner similar to Example 242, 2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide (Example 166a) (50 mg) in 1,4-dioxan (1 ml) and 2-fluoro-3-trifluoromethylphenylamine (Aldrich) (156 mg) were reacted to give the title compound (11 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07635701B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-e547e7c8b23e4e82824450a57fc54f9e |
| Source note | uspto-grants-2009_12 |