反应详情

2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide (116 mg Example 183a), 3-chloro-4-fluoroaniline (ex-Aldrich, 275 mg), and 1,4-dioxan (1.2 ml) were stirred at 100° C. under nitrogen for 6 h. The cooled reaction mixture was evaporated in vacuo, treated with ethyl acetate (5 ml), washed with aqueous 2M hydrochloric acid (2×3 ml), followed by brine, and dried (Na2SO4). The solution was evaporated in vacuo to give the title compound (104 mg).

1. customThe cooled reaction mixture
2. customwas evaporated in vacuo
3. additiontreated with ethyl acetate (5 ml)
4. washwashed with aqueous 2M hydrochloric acid (2×3 ml)
5. dry with materialdried (Na2SO4)
6. customThe solution was evaporated in vacuo