反应详情

2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide (100 mg Example 183a), 2-chloro-5-fluoroaniline (ex-Fluorochem, 237 mg), and 1,4-dioxan (1 ml) were stirred at 100° C. under nitrogen for 18 h. The cooled reaction mixture was evaporated in vacuo, treated with ethyl acetate (5 ml), washed with aqueous 2M hydrochloric acid (2×3 ml), followed by water (2×3 ml), and dried (Na2SO4). The solution was evaporated in vacuo and the residue purified by mass directed auto-preparative purification to give the title compound (35 mg).

1. customThe cooled reaction mixture
2. customwas evaporated in vacuo
3. additiontreated with ethyl acetate (5 ml)
4. washwashed with aqueous 2M hydrochloric acid (2×3 ml)
5. dry with materialdried (Na2SO4)
6. customThe solution was evaporated in vacuo
7. customthe residue purified by mass
8. custompurification