(1-Cyanocyclohexyl)acetic acid → Gabapentin

Participants

Reaction Steps

In U.S. Pat. Nos. 5,132,451, 5,319,135 & 6,294,690, 1-cyanocyclohexane acetic acid was hydrogenated in methanol at room temperature for 2 hours, using 15% Rhodium on carbon catalyst containing 1% palladium. The mixture was filtered and the filtrate concentrated. Addition of isopropanol and stirring at 0-5 deg for 24 hrs gave gabapentin. In EP Patent no 414262B1,1-cyano cyclohexene acetic acid was hydrogenated on Raney nickel to produce Gabapentin.

Provenance & Evidence