Gabapentin hydrochloride → Gabapentin

Participants

Reaction Steps

In WO 0001660, a solution of gabapentin hydrochloride in water was passed over ReliteEXA10 resin and the eluate was concentrated under vacuum. The concentrate was treated with 2-methoxy ethanol and a mixture of water and 2-methoxy ethanol was distilled out. Isopropanol was added to the resultant suspension; the mixture was heated to 60 deg C. for 30 minutes and cooled. After 2 hours at −5 to −10 deg C., the precipitate was filtered to give gabapentin.

Provenance & Evidence