Methyl acetoacetate → HCID 136393284, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1H-1,2,4-triazole-3,5-diamine (1.0 g, 10.1 mmol), methyl 3-oxobutanoate (1.17 g, 10.1 mmol), and 2,4-dichlorobenzaldehyde (1.35 g, 10.1 mmol) in THF (30 mL) and heptane (8 mL) was added piperidine (30 mg, 0.3 mmol) and the reaction was heated to 70° C. for 2 days. The reaction was concentrated to afford crude methyl 2-amino-7-(2,4-dichlorophenyl)-5-methyl-4,7-dihydro-[1,2,4]-triazolo[1,5-a]pyrimidine-6-carboxylate as a light yellow solid.

Provenance & Evidence