Triethylamine → Trimethylsilylethyl 6-((tert-butoxycarbonyl)methyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carbamate

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Reaction Conditions

Reaction Steps

To a stirred solution of 6-((tert-butoxycarbonyl)methyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxylic acid (Example 58, Step 2, 45 mg, 0.1 mmol) in PhCH3 (3 mL) was added DPPA (43 μL, 0.2 mmol), TMSCH2CH2OH (71 μL, 0.5 mmol) and Et3N (31 μL, 0.22 mmol). The reaction was heated to 65° C. for 16 h and was concentrated under reduced pressure. The resulting residue was diluted with EtOAc and extracted with satd aq NH4Cl, NaHCO3 and brine prior to drying over anhydrous MgSO4. Filtration, concentration under reduced pressure and purification by silica gel chromatography afforded trimethylsilylethyl 6-((tert-butoxycarbonyl)methyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carbamate (14 mg, 25%).

Provenance & Evidence