HCID 86606996, compound → HCID 86606995, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl (5-(2,4-dichlorophenyl)-2-(methoxy(methyl)carbamoyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methylcarbamate (intermediate for Example 59, 15 mg, 0.03 mmol) in THF (1 mL) at 0° C. was added MeMgBr (3M in THF, 0.05 mL, 0.15 mmol). After 30 min, the reaction was quenched with satd aq NH4Cl and diluted with EtOAc. The organic layer was washed with satd aq NH4Cl and brine prior to drying over MgSO4. Filtration, concentration under reduced pressure and purification by silica gel chromatography afforded tert-butyl (2-acetyl-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methylcarbamate (10 mg, 73%) as a white solid.

Provenance & Evidence