Sodium borohydride → HCID 86606997, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl (2-acetyl-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methylcarbamate (intermediate for Example 150, 5 mg, 0.01 mmol) in THF (2 mL) and H2O (0.3 mL) at room temperature was added NaBH4 (2 mg, 0.05 mmol). After 30 min, the reaction was concentrated under reduced pressure and diluted with EtOAc. The organic layer was washed with satd aq NH4Cl and brine prior to drying over MgSO4. Filtration, concentration under reduced pressure and purification by silica gel chromatography afforded crude tert-butyl (5-(2,4-dichlorophenyl)-2-(1-hydroxyethyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methylcarbamate (5 mg, 100% crude yield).

Provenance & Evidence