反应详情

温度

80 °C

A suspension of 6-carbamoyl-5-(2,4-dichlorophenyl)-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine-2-sulfonic acid (90 mg, 0.23 mmol) and MnO2 (110 mg, 1.27 mmol) in dioxane (2 mL) was heated to 80° C. for 24 h. HPLC analysis indicated 50% conversion, and additional MnO2 (200 mg) was added and heating was continued for additional 48 h. After removal of catalyst and solvent, 6-carbamoyl-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-sulfonic acid was obtained as a brown solid ˜90% pure (75mg, 82%). The crude product was used for the subsequent reaction without further purification.

1. additionwas added
2. temperatureheating
3. customAfter removal of catalyst and solvent