1,4-Dioxane → (4-Chloro-phenyl)-[4-(4-hydroxy-pyrrolidin-3-yl)-piperazin-1-yl]-methanone

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Reaction Steps

3-[4-(4-Chloro-benzoyl)-piperazin-1-yl]4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (26 g) was dissolved in CH2Cl2 (150 mL). 4M HCL/Dioxane (150 mL) was added. The mixture was stirred at RT for 4 h. White precipitate was formed. The mixture was diluted with ether, filtered. The white solid was washed with ether and dried to give the desired product (99% yield). 1H-NMR (300 MHz, DMSO, HCl salt): δ 3.04.0 (m, 12 H), 4.85 (m, 2 H), 7.25 (d, 2 H), 7.54 (d, 2 H). Retention Time (LC, method: Formic acid polar): 1.01 min. MS (M+H+): 310

Provenance & Evidence