Diethyl Ether → HCID 68508768, compound

HRID 1868503Notes

Reaction equation

HRID 1868503 reaction equation
C([O:5][C:6]([N:8]1[C:12]([CH3:13])=[C:11]([Cl:14])[C:10]([C:15]([F:18])([F:17])[F:16])=[N:9]1)=[O:7])(C)(C)C.Cl.O1CCOCC1.CCOCC>ClCCl>[Cl:14][C:11]1[C:10]([C:15]([F:17])([F:16])[F:18])=[N:9][N:8]([C:6]([OH:7])=[O:5])[C:12]=1[CH3:13]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 204431481,4-Dioxane hydrochlorideHCID 68508572HCID 68508572, compound

Product 1

HCID 68508768HCID 68508768, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 43.62 mmol of 4-chloro-5-methyl-3-trifluoromethylpyrazole-1-carboxylic acid tertbutyl ester in 20 mL of dichloromethane, carefully add 40 mL of 4M HCl/dioxane. The reaction mixture was allowed to stir for 2 hours. Add fresh ether and filter the white solid obtained. Vaccum dry to give the title compound 4-chloro-5-methyl-3-trifluoromethylpyrazole-1-carboxylic acid in 96% yield. LC-MS m/z=242 (M+).

Workup

  1. filtrationfilter the white solid
  2. customobtained
  3. customVaccum dry

Sources & evidence

ORD record
ord-d2e446811f3a4cb78802b0057c78c1ac
Source dataset
uspto-grants-2009_12
Patent number
US07635698B2

Reaction notes

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