Isopropanol → 1-Phenylethanol, (R)-

Participants

Reaction Conditions

Reaction Steps

To the reaction solution obtained in (3) were added acetophenone (0.56 ml, 4.81 mmol) and 2-propanol (9.4 ml, 121 mmol), and the mixture was stirred at 25° C. for 24 hours. The reaction mixture was purified by means of Kugelrohr distillation to give (R)-1-phenylethanol (0.541 g, 92% yield). The asymmetric yield of the product was measured in a HPLC using a CHIRALCEL OD column (4.6×250 mm, Daicel Chemical Industries Ltd) and found to be not less than 99% e.e. In the table below, the results obtained by using a metal-ligand complex 4 (described on page 9800 of J. Am. Chem. Soc. 1993, 115, 9800-9801 and hereinafter referred to as the comparative compound) are also given for comparison.

Provenance & Evidence