反应详情

A mixture of 4.31 g (0.02 mol) of 3-bromo-1-methyl-1H-indole and 0.22 g (0.0004 mol) of NiCl2dppp was added to a solution of p-TolylMgBr in ether (prepared from 0.6 g of Mg (0.025 mol) and 4.21 g of TolylBr (0.024 mol) in 40 mL of ether) under stirring. The reaction mixture was stirred overnight. The resulting mixture was treated with 10% aqueous NH4Cl, the organic layer was separated, washed with 10% aqueous NH4Cl and then dried over anhydrous Na2SO4. The solution was evaporated to give an oil that crystallized. The product was washed with methanol and dried. Yield 2.2 g (49%) of colorless crystalline solid.

1. stirringThe reaction mixture was stirred overnight
2. customthe organic layer was separated
3. washwashed with 10% aqueous NH4Cl
4. dry with materialdried over anhydrous Na2SO4
5. customThe solution was evaporated
6. customto give an oil
7. customthat crystallized
8. washThe product was washed with methanol
9. customdried