HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → (5E)-5-[(4-Hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (5E)-5-[(4-Hydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 1276528 | — |
Reaction Steps
4-(Thiazolidin-2,4-dione-5-ylidinemethyl)-phenol (55) was synthesized by the condensation of 4-hydroxy benzaldehyde (53) with commercially available 2,4-thiazolidinedione (54) using piperidine as base in refluxing ethanol, according to a known procedure (Momose, Y.; Meguro, K.; Ikeda, H.; Hatanaka, C.; Oi, S.; Sohda, T. Chem. Pharm. Bull. 1991, 39, 1440.) (Scheme 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07635779B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-1609fca529b84a5fb2dffc4b615dcbbb |
| Source note | uspto-grants-2009_12 |