1-Phenylpiperazine → HCID 11592740, compound

Participants

Reaction Steps

3′,5′-Dibenzyloxy-7-(2,3-epoxy-propoxy)-flavone, 28 (2.5 g, 4.9 mmol) and 1-phenyl piperazine (0.76 mL, 5 mmol) in dry methanol (180 mL) were reacted in a similar manner to that described under 34 to afford 36. Yield 3.1 g (94%); mp 168-170° C.; MS (FAB) 669 (M++1); IR (KBr) 3389, 1634; 1H NMR (200 MHz, CDCl3) δ 8.12 (d, J=8.6 Hz, 1H), 7.46-7.30 (m, 10H), 7.26-7.23 (m, 2H), 7.11 (d, J=1.9 Hz, 2H), 7.00 (d, J=8.5 Hz, 1H), 6.98 (s, 1H), 6.95-6.86 (m, 3H), 6.76 (s, 1H), 6.69 (s, 1H), 5.09 (s, 4H), 4.21-4.14 (m, 3H), 3.23 (t, J=4.7 Hz, 4.6 Hz, 4H), 2.91-2.81 (m, 2H), 2.66 (dd, J=5.2 Hz, 4.1 Hz, 4H). Analysis Calcd for C42H40N2O6: C, 75.43; H, 6.03; N, 4.19. Found: C, 75.37; H, 6.20; N, 4.13.

Provenance & Evidence