Tert-Butylamine → HCID 11541536, compound

Participants

Reaction Steps

3′,4′-Dibenzyloxy-7-(2,3-epoxy-propoxy)-flavone, 29 (2.5 g, 4.9 mmol) and tert-butyl amine (1.05 mL, 9.8 mmol) in dry methanol (160 mL) were reacted in a similar manner to that described under 34 to afford 37. Yield 2.4 g (85%); mp 159-161° C.; MS (FAB) 580 (M+1); IR (KBr) 3400, 1633; 1H NMR (200 MHz, CDCl3) δ 8.08 (d, J=8.7 Hz, 1H), 7.50-7.28 (m, 12H), 7.02-6.93 (m, 3H), 6.60 (s, 1H), 5.23 (s, 4H), 4.10-3.98 (m, 3H), 2.90 (dd, J=5.9 Hz, 3.8 Hz, 1H), 2.71 (dd, J=5.9 Hz, 7.3 Hz, 1H), 2.47 (s, 2H), 1.14 (s, 9H). Analysis Calcd for C36H37NO6: C, 74.59; H, 6.43; N, 2.42 Found: C, 73.36; H, 6.62; N, 2.39.

Provenance & Evidence