Isopropylamine → HCID 11613861, compound

Participants

Reaction Steps

3′,4′-Dibenzyloxy-7-(2,3-epoxy-propoxy)-flavone, 29 (2.5 g, 4.9 mmol) and iso-propyl amine (1.8 mL, 14.7 mmol) in dry methanol (160 mL) were reacted in a similar manner to that described under 34 to afford 38. Yield 2.4 g (87%); mp 177-179° C.; MS (FAB) 566 (M++1); IR (KBr) 3423, 1635; 1H NMR (200 MHz, CDCl3) δ 8.02 (d, J=8.5 Hz, 1H), 7.70-7.32 (m, 12H), 7.11-6.98 (m, 3H), 6.64 (s, 1H), 5.24 (s, 2H), 5.23 (s, 2H), 4.14-4.09 (m, 3H), 3.05 (s, 2H), 2.92-2.68 (m, 3H), 1.09 (d, J=6.2 Hz, 6H). Analysis Calcd for C35H35NO6: C, 74.32; H, 6.24; N, 2.48. Found: C, 74.46; H, 6.19; N, 2.36.

Provenance & Evidence