Tert-Butylamine → HCID 11612258, compound

Participants

Reaction Steps

3′,4′,5′-Trimethoxy-7-(2,3-epoxy-propoxy)-flavone, 31 (2.1 g, 5.47 mmol) and tert-butyl amine (1.75 mL, 16.4 mmol) in dry methanol (130 mL) were reacted in a similar manner to that described under 34 to afford 40. Yield 2.1 g (84%); mp 119-120° C.; MS (FAB) 458 (M++1); IR (KBr) 3403, 1631; 1H NMR (200 MHz, CDCl3) δ 8.11 (d, J=9.5 Hz, 1H), 7.10 (s, 2H), 7.02-6.99 (m, 2H), 6.70 (s, 1H), 4.14-4.11 (m, 3H), 3.96 (s, 6H), 3.93 (s, 3H), 2.86-2.81 (m, 2H), 1.14 (s, 9H). Analysis Calcd for C25H31NO7: C, 65.63; H, 6.83; N, 3.06. Found: C, 65.47; H, 6.77; N, 3.12.

Provenance & Evidence