Isopropylamine → HCID 11583077, compound

Participants

Reaction Steps

3′,4′,5′-Trimethoxy-7-(2,3-epoxy-propoxy)-flavone, 31 (1.2 g, 3 mmol) and iso-propyl amine (0.78 mL, 9.3 mmol) in dry methanol (120 mL) were reacted in a similar manner to that described under 34 to afford 41. Yield 900 mg (65%); mp 106-107° C.; MS (FAB) 444 (M++1); IR (KBr) 3394, 1631; 1H NMR (200 MHz, CDCl3) δ 8.09 (d, J=9.5 Hz, 1H), 7.10 (s, 2H), 7.10-6.99 (m, 2H), 6.71 (s, 1H), 4.16-4.09 (m, 3H), 3.96 (s, 6H), 3.93 (s, 3H), 2.95-2.82 (m, 3H), 1.14 (d, J=6.2 Hz, 6H).

Provenance & Evidence