1-Phenylpiperazine → HCID 11671153, compound

Participants

Reaction Steps

3′,4′,5′-Trimethoxy-7-(2,3-epoxy-propoxy)-flavone, 31 (1.1 g, 3 mmol) and 1-phenyl piperazine (0.5 mL, 3.27 mmol) in dry methanol (130 mL) were reacted in a similar manner to that described under 34 to afford 42. Yield 1.4 g (85%); mp 170-171° C.; MS (FAB) 547 (M++1); IR (KBr) 3406, 1635; 1H NMR (200 MHz, CDCl3) δ 8.13 (d, J=9.5 Hz, 1H), 7.27 (t, J=7.9 Hz, 2H), 7.10 (s, 2H), 7.04-7.01 (m, 2H), 6.95-6.87 (m, 3H), 6.70 (s, 1H), 4.21-4.12 (m, 3H), 3.95 (s, 6H), 3.93 (s, 3H), 3.23 (t, J=4.6 Hz, 4H), 2.87-2.83 (m, 2H), 2.68-2.65 (m, 4H). Analysis Calcd for C31H34N2O7: C, 68.12; H, 6.27; N, 5.12. Found: C, 68.26; H, 6.37; N, 5.41.

Provenance & Evidence