Tert-Butylamine → HCID 11683340, compound

Participants

Reaction Steps

3′,5′-Dimethoxy-7-(2,3-epoxy-propoxy)-flavone, 32 (500 mg, 1.41 mmol) and tert-butyl amine (0.6 mL, 5.64 mmol) in dry methanol (100 mL) were reacted in a similar manner to that described under 34 to afford 43. Yield 400 mg (66%); mp 145-146° C.; MS (FAB) 428 (M+1); IR (KBr) 3431, 1631; 1H NMR (200 MHz, DMSO-d6) δ 7.93 (d, J=8.8 Hz, 1H), 7.32 (d, J=1.9 Hz, 1H), 7.15 (d, J=2.0 Hz, 2H), 7.08 (dd, J=8.9 Hz, 2.0 Hz, 1H), 6.92 (s, 1H), 6.68 (s, 1H), 4.17-4.01 (m, 3H), 3.82 (s, 6H), 2.77-2.59 (m, 2H), 1.08 (s, 9H). Analysis Calcd for C24H29NO6: C, 67.43; H, 6.84; N, 3.28. Found: C, 67.59; H, 6.73; N, 3.39.

Provenance & Evidence