Isopropylamine → HCID 11661570, compound

Participants

Reaction Steps

3′,5′-Dimethoxy-7-(2,3-epoxy-propoxy)-flavone, 32 (700 mg, 2 mmol) and iso-propyl amine (1.0 mL, 12 mmol) in dry methanol (120 mL) were reacted in a similar manner to that described under 34 to afford 44. Yield 720 mg (87%); mp 155-156° C.; MS (FAB) 414 (M++1); IR (KBr) 3426, 1630; 1H NMR (200 MHz, DMSO-d6) δ 7.95 (d, J=8.9 Hz, 1H), 7.34 (s, 1H), 7.18 (d, J=1.8 Hz, 2H), 7.09 (dd, J=8.9 Hz, 1.9 Hz, 1H), 6.96 (s, 1H), 6.70 (s, 1H), 4.20-3.90 (m, 3H), 3.85 (s, 6H), 2.84-2.58 (m, 3H), 1.03 (d, J=6.2 Hz, 6H). Analysis Calcd for C23H27NO6: C, 66.81; H, 6.58; N, 3.39. Found: C, 66.69; H, 6.13; N, 3.62.

Provenance & Evidence