1-Phenylpiperazine → HCID 11606012, compound

Participants

Reaction Steps

3′,5′-Dimethoxy-7-(2,3-epoxy-propoxy)-flavone, 32 (400 mg, 1.13 mmol) and 1-phenyl piperazine (0.17 mL, 1.13 mmol) in dry methanol (100 mL) were reacted in a similar manner to that described under 34 to afford 45. Yield 490 mg (84%); mp 195-196° C.; MS (FAB) 517 (M++1); IR (KBr) 3417, 1633; 1H NMR (200 MHz, DMSO-d6) δ 7.97 (d, J=8.8 Hz, 1H), 7.40 (d, J=1.9 Hz, 1H), 7.24 (d, J=1.9 Hz (d, J=7.9 Hz, 2H), 7.12 (dd, J=8.9 Hz, 1.9 Hz, 1H), 7.04 (s, 1H), 6.93 (d, J=8.2 Hz, 2H), 6.80 (d, J=7.1 Hz, 1H), 6.74 (s, 1H), 4.25-4.09 (m, 3H), 3.87 (s, 6H), 3.13 (t, J=6.5 Hz, 4H), 2.63 (d, J=4.5 Hz, 2H), 2.47-2.43 (m, 4H). Analysis Calcd for C30H32N2O6: C, 69.75; H, 6.24; N, 5.42. Found: C, 69.61; H, 6.53; N, 5.61.

Provenance & Evidence