Isopropylamine → HCID 11611332, compound

Participants

Reaction Steps

3′,4′-Dimethoxy-7-(2,3-epoxy-propoxy)-flavone, 33 (300 mg, 0.85 mmol) and iso-propyl amine (0.15 mL, 1.7 mmol) in dry methanol (80 mL) were reacted in a similar manner to that described under 34 to afford 46. Yield 290 mg (83%); mp 144-145° C.; MS (FAB) 414 (M++1); IR (KBr) 3410, 1634; 1H NMR (200 MHz, CDCl3) δ 8.03 (d, J=9.5 Hz, 1H), 7.51 (dd, J=8.5 Hz, 1.7 Hz, 1H), 7.36 (d, J=1.7 Hz, 1H), 6.96-6.92 (m, 3H), 6.74 (s, 1H), 4.18-4.12 (m, 3H), 3.97 (s, 3H), 3.96 (s, 3H), 3.99 (s, (m, 3H), 1.23 (d, J=6.3 Hz, 6H). Analysis Calcd for C23H27NO6: C, 66.81; H, 6.58; N, 3.39. Found: C, 66.67; H, 6.65; N, 3.53.

Provenance & Evidence