1-Phenylpiperazine → HCID 11591652, compound

Participants

Reaction Steps

3′,4′-Dimethoxy-7-(2,3-epoxy-propoxy)-flavone, 33 (300 mg, 0.85 mmol) and 1-phenyl piperazine (0.13 mL, 0.85 mmol) in dry methanol (60 mL) were reacted in a similar manner to that described under 34 to afford 47. Yield 410 mg (94%); mp 191-193° C.; MS (FAB) 517 (M++1); IR (KBr) 3416, 1627; 1H NMR (200 MHz, CDCl3) δ 8.16 (d, J=9.5 Hz, 1H), 7.54 (dd, J=8.3 Hz, 2.1 Hz, 1H), 7.34 (d, J=1.9 Hz, 1H), 7.31-7.23 (m, 2H), 7.04-6.87 (m, 6H), 6.70 (s, 1H), 4.21-4.16 (m, 3H), 3.99 (s, 3H), 3.97 (s, 3H), 3.28 (t, J=4.8 Hz, 4H), 2.90-2.71 (m, 2H), 2.71-2.65 (m, 4H). Analysis Calcd for C30H32N2O6: C, 69.75; H, 6.24; N, 5.42. Found: C, 69.96; H, 6.57; N, 5.51.

Provenance & Evidence