HCID 11541536, compound → HCID 11618226, compound

Participants

Reaction Steps

7-(3-tert-Butylamino-2-hydroxy-propoxy)-3′,4′-dibenzyloxy-flavone, 37 (1.4 g, 2.4 mmol) was debenzylated in dry methanol (40 mL) with 10% Pd/C (30 mg) under hydrogen atmosphere as described for 48 to provide 50. Yield 930 mg (97%); mp 165° C. (decomposes); MS (FAB) 400 (M++1); IR (KBr) 3274, 1623; 1H NMR (200 MHz, DMSO-d6) δ 7.95 (d, J=8.8 Hz, 1H), 7.47 (s, 1H), 7.44 (d, J=9.4 Hz, 1H), 7.29 (s, 1H), 7.10 (d, J=8.8 Hz, 1H), 6.95 (d, J=8.1 Hz, 1H), 6.68 (s, 1H), 4.28-4.19 (m, 3H), 3.18-3.14 (m, 1H), 2.97-2.94 (m, 1H), 1.34 (s, 9H). Analysis Calcd for C22H25NO6: C, 66.15; H, 6.31; N, 3.51. Found: C, 66.26; H, 6.27; N, 3.27.

Provenance & Evidence