HCID 11613861, compound → HCID 11639597, compound

Participants

Reaction Steps

3′,4′-Dibenzyloxy-7-(2-hydroxy-3-iso-propylamino-propoxy)-flavone, 38 (1.0 g, 1.77 mmol) was debenzylated in dry methanol (40 mL) with 10% Pd/C (30 mg) under hydrogen atmosphere as described for 48 to provide 51. Yield 600 mg (88%); mp 187° C. (decomposes); MS (FAB) 386 (M++1); IR (KBr) 3425, 1624; 1H NMR (200 MHz, DMSO-d6) δ 7.96 (d, J=7.1 Hz, 1H), 7.47 (s, 1H), 7.45 (d, J=8.2 Hz, 1H), 7.30 (s, 1H), 7.10 (d, J=8.1 Hz, 1H), 6.95 (d, J=7.6 Hz, 1H), 6.68 (s, 1H), 4.23-4.18 (m, 3H), 3.21-3.18 (m, 3H), 1.27 (d, J=6.2 Hz, 6H). Analysis Calcd for C21H23NO6: C, 65.44; H, 6.02; N, 3.63. Found: C, 65.37; H, 6.18; N, 3.47.

Provenance & Evidence