HCID 11534361, compound → HCID 11718263, compound

Participants

Reaction Steps

6-(3-tert-Butylamino-2-hydroxy-propoxy)-3′,4′-dibenzyloxy-flavone, 39 (1.16 g, 2 mmol) was debenzylated in dry methanol (40 mL) with 10% Pd/C (30 mg) under hydrogen atmosphere as described for 48 to provide 52. Yield 740 mg (93%); mp 193° C. (decomposes); MS (FAB) 400 (M++1); IR (KBr) 3399, 1616; 1H NMR (200 MHz, DMSO-d6) δ 7.93 (s, 1H), 7.55 (d, J=9.5 Hz, 1H), 7.53 (s, 1H), 7.39 (d, J=9.8 Hz, 1H), 7.34 (d, J=8.5 Hz, 1H), 6.93 (d, J=8.0 Hz, 1H), 6.62 (s, 1H), 4.41-4.12 (m, 3H), 3.07-2.93 (m, 2H), 1.33 (s, 9H). Analysis. Calcd for C22H25NO6: C, 66.15; H, 6.31; N, 3.51. Found: C, 66.26; H, 6.47; N, 3.61.

Provenance & Evidence