反应详情

Concentrated H2SO4 (5.0 mL, 18.0M) was cooled to −4° C. and treated with diethyl 2-(2-(4-chlorophenyl)-2-methylpropanoyl)malonate (1.00 g, 2.93 mmol). The resulting green solution was warmed to room temperature and allowed to stir for 1 hour. The solution was then poured into a 0° C. chilled mixture of water (10 mL) and heptane (5 mL). The resulting precipitate was collected by vacuum filtration, washed with cold water (10 mL) and heptane (1 mL). The product was dried at 40° C. overnight under vacuum to give 0.69 g of the title compound. MS m/e=295.2 (M+H)+.

1. additionThe solution was then poured into a 0° C.
2. temperaturechilled
3. filtrationThe resulting precipitate was collected by vacuum filtration
4. washwashed with cold water (10 mL) and heptane (1 mL)
5. customThe product was dried at 40° C. overnight under vacuum