Potassium Hydroxide → 2-(4-Fluorophenyl)-2-methylpropanoic acid

HRID 1868646Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1868646
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:4][CH:3]=1.[OH-].[K+]>CCO.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 62393957Ethyl 2-(4-fluorophenyl)-2-methylpropanoate

Produkt 1

HCID 201638032-(4-Fluorophenyl)-2-methylpropanoic acidAusbeute 58,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-(4-fluorophenyl)-2-methylpropanoate (6 g, 29 mmol), KOH (3 g, 57 mmol) and 100 mL EtOH/H2O (4:1) was refluxed for 4 hours. The mixture was cooled to room temperature. The mixture was extracted with EtOAc and the organic layer discarded. The water layer was acidified with concentrated HCl, extracted with EtOAc, washed with H2O and brine, dried over anhydrous Na2SO4, and concentrated in vacuo to give 3.1 g of the product as a white solid. MS m/e=211(M−1)−.

Aufarbeitung

  1. temperaturewas refluxed for 4 hours
  2. extractionThe mixture was extracted with EtOAc
  3. extractionextracted with EtOAc
  4. washwashed with H2O and brine
  5. dry with materialdried over anhydrous Na2SO4
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-067dfeee024e4908bd23ee149c4dd71f
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07635715B2

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