HCID 178451293, compound → HCID 57983434, compound

Participants

Reaction Steps

A mixture of 1,1-dimethylethyl N-((8-fluoro-2-hydroxy-1,1-dimethyl-4-oxo-7-((phenylmethyl)oxyl)-naphthalene-3-yl)carbonyl)glycinate (0.21 g, 447 μmol) in 2 mL TFA was stirred at room temperature for 30 minutes, M+1=414. The mixture was concentrated and then triturated in DCM/hexane (5:10). The solid was filtered, washed with 10 mL DCM/hexane (5:10), and dried under high vacuum to give 0.16 g of a pale yellow solid. LCMS showed about 10% of debenzylated product. The product was further purified by column chromatography eluting with 1:10:100 TFA/MeOH/DCM to give 108 mg of the pure compound. MS (m/z)=414 (M+H)+. Calculated for C22H20FNO6 413.13.

Provenance & Evidence