Hydrochloric Acid → Methyl 2-fluorophenylacetate

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-fluorophenylacetic acid (9.6 g, 62 mmol) in MeOH (100 mL) was added concentrated HCl (0.7 mL, 19 mmol). The mixture was heated at 68° C. for 4 hours, and then the reaction was concentrated in vacuo to remove MeOH. The residue was dissolved in ether and then washed with saturated NaHCO3 solution (1×50 mL). The organic extracts were separated, dried with Na2SO4, filtered, and concentrated in vacuo to give a yellow oil (10 g). MS (m/z)=169.0 (M+H)+.

Provenance & Evidence