反应详情

温度

100 °C

To a solution of bis(4-chlorophenyl)acetic acid (5.00 g, 17.8 mmol) in EtOH (100 mL) in a 500 mL round bottom flask, was added H2SO4, 36N (0.0988 mL, 1.78 mmol). The mixture was stirred at 100° C. for 18 hours. The mixture was then concentrated in vacuo, diluted with EtOAc (200 mL), and washed with deionized water (3×100 mL) and then with brine (100 mL). The organic layer was dried over MgSO4, concentrated, and dried in vacuo to give the crude product ethyl 2,2-bis(4-chlorophenyl)acetate (5.473 g). MS m/e=309 (M+H)+.

1. concentrationThe mixture was then concentrated in vacuo
2. additiondiluted with EtOAc (200 mL)
3. washwashed with deionized water (3×100 mL)
4. dry with materialThe organic layer was dried over MgSO4
5. concentrationconcentrated
6. customdried in vacuo