反应详情

A solution of the crude diethyl 2-(2-(4-bromophenyl)-2-methylpropanoyl)malonate (4982 mg, 12932 μmol) in concentrated H2SO4 (30 mL) was stirred at 23° C. After 2 hours, the reaction was poured into an ice-water mixture (200 mL) and extracted with EtOAc (3×200 mL). The combined organic layers were washed with brine (100 mL), dried over MgSO4, and concentrated in vacuo affording ethyl 6-bromo-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-carboxylate as the product.

1. extractionextracted with EtOAc (3×200 mL)
2. washThe combined organic layers were washed with brine (100 mL)
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo