Sulfuric Acid → HCID 67099630, compound

Participants

Reaction Steps

Diethyl 2-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)malonate (2.80 g, 7.5 mmol) was added to H2SO4 (40 mL, 237 mmol), and the mixture was stirred at room temperature for 1 hour. Ice (H2O) was added, and the aqueous mixture was extracted with EtOAc (2×). The combined organic layers were washed with water (2×) and brine, dried (MgSO4), and concentrated in vacuo to give the crude compound as a yellow oil. The crude oil was purified by silica flash chromatography (0-50% DCM/hexane) to give the desired compound as a yellow semi-solid (1.07 g). MS (m/e)=329.1 (M+H)+.

Provenance & Evidence