Phosphorus oxide (P4O10) → HCID 67099749, compound

Participants

Reaction Steps

To diethyl 2-(2-(4-chloro-2-fluorophenyl)-2-methylpropanoyl)malonate (2.20 g, 6.1 mmol), was added P2O5 (3.5 g, 25 mmol) in H2SO4 (3.3 mL) at 0° C. The reaction was then allowed to warm to ambient temperature and stirred for 1 hour. The reaction mixture was poured into ice, diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 2 times with 75 mL of water, separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (0.75 g) which was used without further purification. MS (m/z)=313 (M+H)+.

Provenance & Evidence