Diisopropylethylamine → HCID 67100102, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 6-chloro-8-fluoro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-carboxylate (0.75 g, 2398 μmol) was dissolved in 1,4-dioxane (4797 μL) and N-ethyl-N-isopropylpropan-2-amine (1253 μL, 7195 μmol). tert-Butyl 2-aminoacetate hydrochloride (603 mg, 3597 μmol) was added, and the reaction was stirred at 80° C. for 3 hours. The reaction was then diluted with 150 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 75 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (227 mg) as a white solid. MS (m/z)=420(M+Na)+.

Provenance & Evidence