Diisopropylethylamine → HCID 67100235, compound

Participants

Reaction Steps

Ethyl 6,7-difluoro-4-hydroxy-2-oxo-2′,3′,5′,6′-tetrahydro-spiro[naphthalene-1,4′-pyran]-3-carboxylate (1.06 g, 3133 μmol) was dissolved in 1,4-dioxane (3133 μL) and N-ethyl-N-isopropylpropan-2-amine (1637 μL, 9400 μmol). tert-Butyl 2-aminoacetate hydrochloride (788 mg, 4700 μmol) was added, and the reaction was placed in a microwave at 140° C. for 10 minutes. The reaction mixture was then diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 50 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound as a white solid after purification via preparatory LC. MS (m/z)=424 (M+H)+.

Provenance & Evidence