Diisopropylethylamine → HCID 67100099, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl 6,7-difluoro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-carboxylate (570 mg, 1924 μmol) in 1,4-dioxane (3848 μL) and N-ethyl-N-isopropylpropan-2-amine (1005 μL, 5772 μmol), was added tert-butyl 2-aminoacetate hydrochloride (484 mg, 2886 μmol). The reaction was then heated at 80° C. for 3 hours. The reaction mixture was then diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 50 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (312 mg) as a white solid after flash chromatography. MS (m/z)=404(M+Na)+.

Provenance & Evidence