Trifluoromethanesulfonic acid → HCID 67099727, compound

Participants

Reaction Steps

Triflic acid (40.4 mL) was added dropwise via addition funnel to diethyl 2-(1-(4-chlorophenyl)cyclohexanecarbonyl)malonate (17.65 g, 46.3 mmol) at 0° C. The resulting mixture was stirred for 1 hour and then poured into a beaker of ice. The resulting mixture was diluted with 150 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 2 times with 75 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (7.24 g) which was used without further purification. MS (m/z)=335 (M+H)+.

Provenance & Evidence