Methanol → Methyl 2-(3,4-dichlorophenyl)acetate

HRID 1868795Notes

Reaction equation

HRID 1868795 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].S(Cl)(Cl)(=O)=O.[CH3:18]O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH3:18])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 887MethanolHCID 24648Sulfuryl chlorideHCID 798743,4-Dichlorophenylacetic acid

Product 1

HCID 1268257Methyl 2-(3,4-dichlorophenyl)acetate

Procedure

2-(3,4-Dichlorophenyl)acetic acid (25.0 g, 122 mmol) was dissolved in MeOH (122 mL) at ambient temperature. Sulfuryl dichloride (8.89 mL, 122 mmol) was then added, and the mixture was stirred for 2 hours. The reaction mixture was concentrated in vacuo to give the title compound as a light yellow oil which was used without further purification. MS (m/z)=219 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ab4ce391d8ab4a75a108b2b840638a38
Source dataset
uspto-grants-2009_12
Patent number
US07635715B2

Reaction notes

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