Diisopropylethylamine → HCID 67099892, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 6,7-dichloro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-carboxylate (325 mg, 987 μmol) was dissolved in 1,4-dioxane (987 μL) and N-ethyl-N-isopropylpropan-2-amine (516 μL, 2962 μmol). tert-Butyl 2-aminoacetate hydrochloride (248 mg, 1481 μmol) was added, and the reaction was stirred at 80° C. for 4 hours. The reaction mixture was then diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 20 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (235 mg) as an off-white solid after purification via preparatory LC. MS (m/z)=358(M+H-tBu)+.

Provenance & Evidence