Sulfuric Acid → HCID 67099888, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of P2O5 (33.0 g, 232 mmol) in concentrated H2SO4 (29.5 mL, 531 mmol) was cooled 0° C. At 0° C., the suspension was added to diethyl 2-(2-(4-chloro-3-fluorophenyl)-2-methylpropanoyl)malonate (2.90 g, 8.20 mmol), and the mixture was stirred at 25° C. for 1 hour. The reaction was quenched with ice. On melting, it was extracted with EtOAc (3×100 mL), washed with water (150 mL), and then with brine (100 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to give the title compound (1.349 g, 52.6% yield) as a tan solid. MS m/e=313.3 (M+H)+.

Provenance & Evidence