Phosphorus oxide (P4O10) → HCID 67099819, compound

Participants

Reaction Conditions

Reaction Steps

P2O5 (1.43 g, 10.1 mmol) was suspended in H2SO4 (5.38 mL) and cooled to 0° C. Diethyl 2-(2-(3-chloro-4-fluorophenyl)-2-methylpropanoyl)malonate (3.62 g, 10.1 mmol) was added, and the reaction was stirred at 0° C. for 1 hour. The reaction mixture was poured into ice, diluted with 150 mL of diethyl ether, added to a separatory funnel, partitioned with water, washed with water (2×75 mL), separated, dried over Na2SO4, and concentrated in vacuo to the title compound (1.46 g) as a white amorphous solid after flash chromatography. MS m/e=313 (M+H)+.

Provenance & Evidence