Diisopropylethylamine → HCID 67100018, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 7-chloro-6-fluoro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-carboxylate (820 mg, 2622 μmol) was dissolved in 1,4-dioxane (5244 μL) and N-ethyl-N-isopropylpropan-2-amine (1370 μL, 7866 μmol). tert-Butyl 2-aminoacetate hydrochloride (659 mg, 3933 μmol) was added, and the reaction was stirred at 80° C. for 3 hours. The reaction mixture was then diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with NaHCO3 (saturated, aqueous), washed 2 times with 50 mL of NaHCO3 (saturated, aqueous), separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (200 mg) as a white solid after flash chromatography. MS m/e 420 (M+Na)+.

Provenance & Evidence